Teratoma
General: Also in the category of nonseminomatous germ cell tumor, teratomas are classified as mature (adult) or immature. Any component of a teratoma may become neoplastic according to its tissue of differentiation.
- Mature teratoma: 5-10% of all testicular neoplasms. Predominantly cystic and multiloculated. Foci of cartilage, neural tissue, and various types of epithelium are most common; bone is infrequent. However, all tissues must be well differentiated. The "dermoid cyst" variation (full of sebum, hair, and keratin) is common in the ovary but rare in the testis.
- Immature teratoma: Morphologic immaturity of any component of a teratoma earns it this designation (although the prognostic significance is not clear).
Gross:
Microscopic: Cellular differentiation, usually a combination of endodermal, mesodermal, and ectodermal tissues.
Differential Diagnosis:
Stains:
- Positive:
- Negative:
- Suggested, focused panel:
(1)
Cases:
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