Reticulin stain(s)

General: Highlight both basement membrane material and so-called reticulin fibers (mainly type IV collagen and laminin), NOT to be confused with reticulum cells. Most are silver based.

Specificity: Type IV collagen and laminin.

Staining characteristics: Black.

Function: Many possible uses, such as distinguishing epithelial from non-epithelial neoplasms, some mesenchymal neoplasms from one another, and in-situ from invasive carcinoma. Most commonly used in hematopathology in the evaluation of bone marrow biopsies.

Normal cell distribution: Basement membranes.


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