Neurofibroma
General: Sporadic and solitary or multiple, or multiple "classically" in the setting of neurofibromatosis type 1. Sporadic etiology typically affects 20-40 year olds, but they may appear at a much younger age in neurofibromatosis. There are multiple variants, some of more significance.
Gross: Fusiform, rubbery, grey and glistening.
Microscopic: Arise within a nerve, but often extend beyond epineurium into soft tissue. Typically more cellular centrally, and more edematous peripherally.
Differential Diagnosis:
Stains:
- Positive: S100 in associated Schwann cells, CD34 in endoneurial fibroblasts
- Negative:
- Suggested, focused panel:
((()))
This site contains private study notes and is under construction, constant re-organization, and updating/correction. Although effort is made to ensure the accuracy of the contents, it should NOT be considered an authoritative medical reference. Thank you.