Histoplasma capsulatum (Histoplasmosis)

General: Fungal infection.

Gross:

Microscopic: Chronic suppurative &/or granulomatous lesions. Lymph nodes may have marked sinus histiocytosis and may progress to widespread nodal necrosis.

Stains: Rarely, may require culture or molecular testing to prove.

• Positive: GMS+, PAS+, (?PAS-Gridley?)
• Negative:
• Suggested panel:

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Images:

Note the histiocytes packed with small blue fungal organisms.

Cases: